CCL20, also known as Macrophage Inflammatory Protein 3 Alpha (MIP-3α), is a cytokine belonging to the C-C chemokine family. It is primarily secreted by various cell types including macrophages and is involved in the immune response, particularly in the recruitment of lymphocytes to inflammatory sites. CCL20 interacts specifically with the CCR6 receptor and plays a significant role in T cell signaling and regulating immune responses. Its relevance extends to various pathological conditions, including autoimmune diseases and cancer, making it a critical focus for researchers in immunology and therapeutic development.