Recombinant Human Pleiotrophin Gly33-Asp168

Recombinant Human Pleiotrophin is a secreted growth factor that mediates signaling through cell-surface proteoglycan and non-proteoglycan receptors. This pleiotrophin family member regulates critical cellular processes including proliferation, survival, growth, differentiation, and migration in neural and bone tissues. It binds to PTPRZ1, ALK, and integrins to activate PI3K-AKT and MAPK pathways. The protein plays important roles in synaptic plasticity, dendritic development, oligodendrocyte differentiation, and bone formation. In neural development, it promotes neurite outgrowth and dendritic arborization. Our high-purity recombinant protein is ideal for studying neurodevelopment, bone mineralization, and associated signaling pathways in research applications.