AB-01115
Anti-CDK11b Antibody
Synonimy: Cell division cycle 2-like protein kinase 1 (CLK-1), Cell division protein kinase 11B, p58 CLK-1
This antibody targets Cyclin-dependent kinase 11B (CDK11B), a serine/threonine kinase belonging to the CDK family, specifically recognizing the p110 isoform. CDK11B(p110) plays crucial roles in coordinating transcription with pre-mRNA splicing, associating with both transcriptional machinery and spliceosomal components. Its expression and activity are cell cycle-regulated, peaking in G2/M phase. Shorter isoforms (p58/p46), generated via alternative mechanisms or caspase cleavage, are implicated in promoting apoptosis.
Validated for applications including immunofluorescence, immunohistochemistry, and flow cytometry, this antibody provides a valuable tool for investigating the functions of CDK11B(p110). Researchers can use it to study the coupling of transcription and RNA splicing, cell cycle-dependent gene expression regulation, G2/M phase progression, and potentially the mechanisms linking CDK11 isoforms to apoptosis.
- IsotypeIgG1
- ClonalityMonoclonal
- FormaLyophilizate
- ShippingAmbient
- Animal FreeYes
- Accession numberP21127
- Przechowywanie-20°C
Informacje o zamówieniu
Dostępny:
Wysyłka do:Australia, Austria, Belgia, Brazylia, Bułgaria, Kanada, Chiny, Dania, Finlandia, Francja, Niemcy, Grecja, Węgry, Islandia, Indie, Irlandia, Włochy, Japonia, Łotwa, Holandia, Norwegia, Polska, Portugalia, Rumunia, Słowacja, Słowenia, Hiszpania, Szwecja, Szwajcaria, Zjednoczone Emiraty Arabskie, Wielka Brytania, Stany Zjednoczone
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