This antibody targets CD163, a transmembrane scavenger receptor predominantly expressed on the surface of monocytes and macrophages, particularly those with an M2 polarization. CD163 plays a key role in clearing hemoglobin-haptoglobin complexes, thereby mediating anti-inflammatory responses and protecting tissues from heme-induced oxidative stress.

This antibody is validated for immunofluorescence, immunohistochemistry, and flow cytometry applications. It is a valuable marker for identifying specific macrophage populations, studying inflammation resolution, iron recycling processes, and investigating macrophage roles in various diseases, including infections and cancer.