TG-01143
Recombinant Human BRCA1 Met1-His1863
Synonyms: RING finger protein 53, RING-type E3 ubiquitin transferase BRCA1
BRCA1 (Breast Cancer Type 1 Susceptibility Protein) is a critical tumor suppressor that plays a central role in DNA repair, cell cycle regulation, and genomic stability maintenance. This nuclear phosphoprotein functions as an E3 ubiquitin-protein ligase, specifically mediating 'Lys-6'-linked polyubiquitin chains. BRCA1 is part of the BRCA1-associated genome surveillance complex (BASC) and interacts with various proteins involved in DNA damage response. It is expressed in breast and ovarian tissues, among others. Mutations in BRCA1 are strongly associated with increased risk of breast and ovarian cancers, making it a crucial target for cancer research and therapeutic development.
- TagHis-Tag
- Biological activityNot tested
- SpeciesHuman
- FormLyophilizate
- ShippingAmbient
- Expression systemE. coli
- Molecular mass (kDa)209.1
- Accession numberP38398
- Storage-20°C
Ordering info
Available:3 - 14 days
Shipping to:Canada, United States
Frequently asked questions
Contact us
Didn't find what you need?
Our scientists and operation team are available to answer any questions you have. Send us a message, and a member of our team will get back to you shortly.