Recombinant Human BMP-4 Ser293-Arg408

Bone morphogenetic protein 4 (BMP-4) is a member of the TGF-beta superfamily of cytokines that plays essential roles in embryonic development and tissue homeostasis. It is involved in mesenchyme formation, epidermal determination, neurogenesis, angiogenesis, and osteogenesis. BMP-4 initiates signaling by binding to type I and type II serine/threonine kinase receptors, activating SMAD-dependent and independent pathways. It is crucial for stem cell differentiation, including cardiac, hematopoietic, and neural lineages. Dysregulation of BMP-4 is associated with various developmental disorders and cancers, making it an important target for research and therapeutic development.