Recombinant Human Nerve Growth Factor (NGF) Ser122-Ala241

Nerve Growth Factor (NGF) is a critical polypeptide involved in the growth, maintenance, and survival of sympathetic and sensory neurons. It acts as an extracellular ligand for the NTRK1 (TrkA) and NGFR receptors, initiating cellular signaling cascades that regulate neuronal proliferation, differentiation, and survival. The mature NGF, composed of two identical beta chains, is essential for the development of peripheral nervous system neurons and maintaining cholinergic neurons' function in the central nervous system. Furthermore, NGF has implications in neurodegenerative diseases through its various signaling roles, including regulating apoptosis and promoting neuronal growth. This features make NGF a vital tool for researchers in neurobiology and related fields.