Recombinant Human BDNF His129-Arg247

Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors. It plays a crucial role in the development, survival, and plasticity of neurons in both the central and peripheral nervous systems. BDNF binds to and activates the TrkB receptor tyrosine kinase, triggering signaling cascades that promote neuronal growth, differentiation, and survival. It is widely expressed in the brain, particularly in the hippocampus and cortex, where it regulates synaptic transmission and plasticity. BDNF is implicated in learning, memory formation, and mood regulation. Altered BDNF levels have been associated with various neurological and psychiatric disorders, making it an important target for neuroscience research and potential therapeutic interventions.