Recombinant Human AXL Ala26-Pro449

AXL is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, migration, and differentiation. It belongs to the TAM family of receptors and is activated by binding to its ligand Growth Arrest-Specific 6 (GAS6). AXL is involved in various signaling pathways, including PI3K/AKT and MAPK, and interacts with proteins such as GRB2, PLCG1, and PIK3R1. Highly expressed in metastatic tumors, AXL is implicated in cancer progression, metastasis, and drug resistance. It also functions in dampening immune responses and clearing apoptotic cells, making it a promising target for cancer therapeutics and immunomodulation.