Recombinant Human Bcl-2 Ser2-Lys233

Bcl-2 (B-cell CLL/lymphoma 2) is a crucial anti-apoptotic protein that plays a significant role in regulating cell death by controlling mitochondrial membrane permeability. It interacts with other members of the Bcl-2 family, demonstrating both pro- and anti-apoptotic functions. The expression of Bcl-2 is particularly important in various lymphoproliferative diseases such as follicular lymphomas, where its overexpression leads to the inhibition of apoptosis, allowing neoplastic cells to survive. Bcl-2 is also involved in inflammation modulation and cellular responses to growth factors, making it essential for understanding mechanisms in cancer biology and therapeutic interventions.