Recombinant Escherichia coli Tetracycline Repressor Protein Class B from Transposon Tn10 Ser2-Ser207 (E. coli, His-Tag)

The tetracycline repressor protein (TetR) is a key regulator of tetracycline resistance in bacteria. It belongs to the TetR family of transcriptional regulators and functions by binding to operator sequences to repress transcription of tetracycline resistance genes. TetR's N-terminal region forms a helix-turn-helix DNA-binding motif, while the C-terminal region binds tetracycline. When tetracycline binds to TetR, it causes a conformational change that reduces TetR's affinity for DNA, allowing expression of resistance genes. This protein plays a crucial role in antibiotic resistance mechanisms and is an important target for studying gene regulation and developing novel antibiotics.