Recombinant Human p53 Ser96-Leu289

The p53 protein, also known as tumor protein p53, is a multifunctional transcription factor that plays a pivotal role in cellular stress response, including cell cycle arrest, DNA repair, and apoptosis. As a potent tumor suppressor, p53 regulates the expression of genes involved in these processes, notably activating cyclin-dependent kinase inhibitors such as p21. Upon DNA damage, p53 mediates apoptosis through interactions with key proteins such as BAX and FAS, with its activity modulated by various isoforms and interactions. p53 is also involved in maintaining genomic stability and orchestrates responses to environmental stressors, making it a critical target in cancer research and therapeutic interventions.