Recombinant Human Lamin B1 Ser1-Gly586

Lamin B1, also known as LMNB1, is a crucial intermediate filament protein that forms part of the nuclear lamina, providing structural support to the nuclear envelope and playing key roles in chromatin organization and nuclear assembly. This protein is critical in maintaining nuclear integrity throughout the cell cycle, with its dynamics being tightly regulated during cell division. Lamin B1 has implications in various diseases, including adult-onset leukodystrophy, where duplications of the LMNB1 gene have been linked to neuropathological changes. Its expression occurs primarily within the nucleus, and Lamin B1’s interactions with chromatin are vital for maintaining genomic stability, making it essential for laboratory studies in cell biology and disease research.