Recombinant Human GTPase KRas Thr2-Arg164

KRAS, a member of the RAS oncogene family, plays a critical role in intracellular signaling pathways that regulate cell proliferation and differentiation. This protein binds GDP/GTP and possesses intrinsic GTPase activity, which is important for transmitting signals from cell surface receptors. In particular, KRAS is known to be an oncogenic driver; it can induce transcriptional silencing of tumor suppressor genes in colorectal cancer cells, thus contributing to tumorigenesis. Its role in cancer biology makes KRAS a valuable target for research in therapeutics and diagnostics, especially for understanding mutations that lead to various malignancies.