Recombinant Human Ki-67 Trp2-Glu100

Ki-67, also known as MKI67, is a nuclear protein crucial for cell proliferation and is a well-established marker for tumor growth. It plays a vital role in the maintenance of mitotic chromosomes, preventing their collapse and ensuring independent chromosomal movement. This protein preferentially binds to supercoiled and AT-rich DNA, contributing indirectly to chromatin organization during cell division. Its expression levels are correlated with increased cellular proliferation, making it an essential target in cancer research, particularly in assessing the growth fraction of various tumors, including breast cancer. Elevated Ki-67 levels are often associated with poorer prognoses, thus underscoring its relevance as a prognostic marker.