Recombinant Human PCNA Phe2-Ser261

Proliferating Cell Nuclear Antigen (PCNA) is a critical protein involved in DNA replication and repair. It acts as a processivity factor for DNA polymerase delta and epsilon, tethering the polymerase to DNA for efficient synthesis. PCNA forms a toroidal trimer during S phase, enabling loading of DNA polymerases onto the replication complex. It plays key roles in cell cycle progression and DNA damage response pathways. PCNA interacts with numerous proteins involved in DNA metabolism and cell cycle control. It is expressed in proliferating cells and cancer cells, making it an important marker for cell proliferation and potential therapeutic target.