Recombinant Human NAD(P)H dehydrogenase [quinone] 1 Met1-Lys274

Recombinant Human NAD(P)H dehydrogenase [quinone] 1 (NQO1) is a flavin-containing quinone reductase that catalyzes the two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. It functions primarily through quinone detoxification and regulation of cellular redox state, producing antioxidant hydroquinone forms that may act as superoxide scavengers. NQO1 also protects tumor suppressors TP53 and TP73 from ubiquitin-independent degradation by the 20S proteasome during oxidative stress. Located in the cytoplasm and cytosol, NQO1 plays crucial roles in cell redox homeostasis, response to oxidative stress, and the metabolism of ubiquinone, vitamin E, and vitamin K. Loss-of-function variants of NQO1 have been linked to increased susceptibility to various forms of cancer.