Anti-PECAM1 Antibody

This antibody targets Platelet Endothelial Cell Adhesion Molecule (PECAM-1/CD31), a 130-140 kDa type I integral membrane glycoprotein expressed on endothelial cells, platelets, and leukocytes. PECAM-1 plays a critical role in leukocyte transendothelial migration during inflammatory responses and contributes to endothelial cell-cell adhesion at intercellular junctions. The protein contains six Ig-like C2-type domains in its extracellular region and is involved in multiple signaling pathways that regulate vascular integrity.

This antibody has been validated for immunofluorescence, immunohistochemistry, and flow cytometry applications, making it suitable for detecting PECAM-1 expression in various experimental contexts. The antibody recognizes the extracellular domain of PECAM-1, allowing detection of the protein in its native conformation on the cell surface.