Anti-LC3B Antibody

This antibody specifically recognizes human LC3B (microtubule-associated proteins 1A/1B light chain 3B), a key protein involved in autophagy processes. LC3B functions as a critical marker for autophagosome formation and plays essential roles in autophagosomal vacuole formation, mitophagy, and the regulation of mitochondrial turnover during cellular stress. It exists in two forms: the cytosolic LC3B-I (18 kDa) and the membrane-bound LC3B-II (16 kDa), with the conversion between these forms serving as a reliable indicator of autophagy activity.

This antibody has been validated for use in immunofluorescence, immunohistochemistry, and flow cytometry applications, making it suitable for researchers studying autophagy pathways and organelle quality control.