Anti-Ki-67 Antibody

This recombinant antibody specifically recognizes human Ki-67 (MKI67), a nuclear protein essential for cell proliferation and a well-established marker for assessing tumor growth. Ki-67 plays a critical role in mitotic chromosome maintenance, preventing chromosome collapse during cell division and ensuring independent chromosomal movement. The protein preferentially binds to supercoiled and AT-rich DNA regions, contributing to chromatin organization during cellular division.

The antibody is optimized for immunofluorescence, immunohistochemistry, and flow cytometry applications, making it valuable for researchers studying cellular proliferation in cancer and other cell growth-related investigations. Its expression is tightly correlated with cell cycle activity, being detectable during G1, S, G2, and M phases but absent in quiescent (G0) cells.