AB-01042
Anti-IKB alpha Antibody
Synonyms: I-kappa-B-alpha (IkB-alpha; IkappaBalpha), Major histocompatibility complex enhancer-binding protein MAD3
This antibody specifically targets NF-kappa-B inhibitor alpha (NFKBIA), a key regulatory protein that inhibits NF-kappa-B transcription factor activity by sequestering REL dimers in the cytoplasm through masking of their nuclear localization signals. Upon cellular stimulation by immune and pro-inflammatory responses, NFKBIA becomes phosphorylated at Ser32/Ser36, leading to its ubiquitination and degradation, which enables translocation of NF-kappa-B to the nucleus where it activates gene transcription.
This antibody has been validated for immunofluorescence, immunohistochemistry, and flow cytometry applications, making it a versatile tool for studying NF-kappa-B signaling pathways in research settings.
- IsotypeIgG1
- ClonalityMonoclonal
- FormLyophilizate
- ShippingAmbient
- Animal FreeYes
- Accession numberP25963
- Storage-20°C
Ordering info
Available:1 - 7 days
Shipping to:Australia, Austria, Belgium, Brazil, Bulgaria, Canada, China, Denmark, Finland, France, Germany, Greece, Hungary, Iceland, India, Ireland, Italy, Japan, Latvia, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, United Arab Emirates, United Kingdom, United States
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