AB-01013
Anti-HIF1A Antibody
Synonyms: ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78 (bHLHe78), Member of PAS protein 1 1 publication, PAS domain-containing protein 8
This monoclonal antibody specifically targets Hypoxia-inducible factor 1-alpha (HIF-1α), a master transcriptional regulator that orchestrates cellular adaptation to hypoxic conditions. HIF-1α functions by heterodimerizing with ARNT to bind hypoxia response elements in promoters of over 40 target genes, activating pathways that increase oxygen delivery and facilitate metabolic adaptation to hypoxia. The protein plays essential roles in embryonic vascularization, tumor angiogenesis, and pathophysiology of ischemic disease.
This antibody has been validated for immunofluorescence, immunohistochemistry, and flow cytometry applications, enabling visualization of HIF-1α in various experimental contexts. The antibody allows researchers to study HIF-1α's dynamic regulation in response to oxygen tension changes and its critical role in cellular stress responses.
- IsotypeIgG1
- ClonalityMonoclonal
- FormLyophilizate
- ShippingAmbient
- Animal FreeYes
- Accession numberQ16665
- Storage-20°C
Ordering info
Available:3 - 14 days
Shipping to:Canada, United States
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