AB-01161
Anti-CD40-L Antibody
Synonyms: CD40 ligand, T-cell antigen Gp39, TNF-related activation protein (TRAP)
This antibody targets CD40 Ligand (CD40L), also known as CD154 or TRAP, a type II transmembrane protein belonging to the TNF superfamily. CD40L is transiently expressed primarily on activated CD4+ T cells and interacts with CD40, which is expressed on antigen-presenting cells (APCs) like B cells, macrophages, and dendritic cells. This interaction is crucial for T cell-dependent B cell activation, immunoglobulin class switching, germinal center formation, and licensing dendritic cells for effective cytotoxic T cell priming.
Validated for immunofluorescence, immunohistochemistry, and flow cytometry applications, this antibody enables the study of T cell-B cell collaboration, APC activation, humoral immunity development, germinal center dynamics, and is relevant for understanding immunodeficiencies (like Hyper-IgM syndrome) and autoimmune diseases.
- IsotypeIgG1
- ClonalityMonoclonal
- FormLyophilizate
- ShippingAmbient
- Animal FreeYes
- Accession numberP29965
- Storage-20°C
Ordering info
Available:1 - 7 days
Shipping to:Australia, Austria, Belgium, Brazil, Bulgaria, Canada, China, Denmark, Finland, France, Germany, Greece, Hungary, Iceland, India, Ireland, Italy, Japan, Latvia, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, United Arab Emirates, United Kingdom, United States
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