Anti-CD123 Antibody

This antibody targets CD123 (IL-3 receptor alpha chain), a cytokine receptor subunit expressed primarily on hematopoietic progenitor cells, plasmacytoid dendritic cells (pDCs), and certain leukemic blasts. CD123 forms the high-affinity receptor for interleukin-3 (IL-3) in conjunction with the common beta chain (CD131), mediating downstream signaling pathways that govern cell proliferation, differentiation, and survival, particularly within the myeloid lineage.CD123 is notably overexpressed in several hematologic malignancies, including acute myeloid leukemia (AML) and blastic plasmacytoid dendritic cell neoplasm (BPDCN), making it a valuable diagnostic and therapeutic target.This antibody has been validated for immunofluorescence, flow cytometry, and immunohistochemistry applications, enabling precise identification and characterization of CD123-positive populations in blood, bone marrow, and tissue samples. It is ideally suited for research in hematopoiesis, leukemia biology, immune regulation, and targeted immunotherapy development.