AB-01129
Anti-BRD4 Antibody
Synonyms: Protein HUNK1
This antibody targets Bromodomain-containing protein 4 (BRD4), a prominent member of the BET (Bromodomain and Extra-Terminal domain) family of epigenetic readers. BRD4 recognizes and binds to acetylated lysine residues on histone tails, particularly H3 and H4, tethering transcriptional regulatory complexes, including the positive transcription elongation factor b (P-TEFb), to chromatin. This promotes transcriptional elongation, particularly at enhancers and super-enhancers controlling key oncogenes like MYC.
Validated for immunofluorescence, immunohistochemistry, and flow cytometry, this antibody is crucial for studying epigenetic regulation, transcriptional control, chromatin structure, and the development of BET inhibitors as therapeutic agents, particularly in cancer research.
- IsotypeIgG1
- ClonalityMonoclonal
- FormLyophilizate
- ShippingAmbient
- Animal FreeYes
- Accession numberO60885
- Storage-20°C
Ordering info
Available:1 - 7 days
Shipping to:Australia, Austria, Belgium, Brazil, Bulgaria, Canada, China, Denmark, Finland, France, Germany, Greece, Hungary, Iceland, India, Ireland, Italy, Japan, Latvia, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, United Arab Emirates, United Kingdom, United States
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