Anti-BRCA1 Antibody

This antibody targets Breast Cancer Type 1 Susceptibility Protein (BRCA1), a 207.7 kDa nuclear phosphoprotein that functions as an E3 ubiquitin-protein ligase mediating the formation of 'Lys-6'-linked polyubiquitin chains. BRCA1 plays a central role in DNA damage repair, maintaining genomic stability, and cell cycle regulation following DNA damage. As part of the BRCA1-BARD1 heterodimer, it coordinates diverse cellular pathways including DNA repair, ubiquitination, and transcriptional regulation.Optimized for immunofluorescence, immunohistochemistry, and flow cytometry applications, this antibody enables detection of BRCA1 in both normal cellular contexts and in cancer research settings where BRCA1 function is frequently altered.