Anti-ATM Antibody

This antibody targets ATM (Ataxia Telangiectasia Mutated), a serine/threonine protein kinase that plays a central role in the cellular response to DNA double-strand breaks. ATM is a key regulator of the DNA damage response (DDR), where it orchestrates cell cycle arrest, DNA repair, and apoptosis through phosphorylation of critical downstream targets such as p53, H2AX, and CHK2. Its activity is crucial for maintaining genomic stability, especially in dividing cells or under genotoxic stress.This antibody has been validated for immunofluorescence, immunohistochemistry, making it suitable for studying DNA damage signaling, cell cycle checkpoints, genomic maintenance mechanisms, and the molecular pathogenesis of cancer and neurodegenerative disorders. It enables investigation of ATM localization, activation (e.g., via phosphorylation at Ser1981), and dynamic recruitment to sites of DNA damage, supporting research in oncology, radiobiology, and genome integrity.