AB-01372
Anti-ACVRL1 Antibody
Synonyms: Activin receptor-like kinase 1 (ALK-1) Serine/threonine-protein kinase receptor R3 (SKR3) TGF-B superfamily receptor type I (TSR-I)
This antibody targets Activin A receptor-like type 1 (ACVRL1), also known as ALK1, a type I cell surface receptor serine/threonine kinase of the TGF-β receptor superfamily. ACVRL1 is primarily expressed in endothelial cells and plays a crucial role in angiogenesis and vascular development by mediating BMP9 and BMP10 signaling. Upon ligand binding, ACVRL1 forms a receptor complex that phosphorylates SMAD1/5/8 proteins, leading to transcriptional regulation of genes involved in endothelial proliferation and vessel maturation.ACVRL1 is of particular interest in research on hereditary hemorrhagic telangiectasia (HHT), vascular malformations, and tumor angiogenesis. This antibody, validated for immunohistochemistry and immunofluorescence, is an essential tool for studying endothelial signaling pathways, vascular remodeling, and related diseases.
- IsotypeIgG1
- ClonalityMonoclonal
- FormLyophilizate
- ShippingAmbient
- Animal FreeYes
- Accession numberP37023
- Storage-20 degree
Ordering info
Available:1 - 7 days
Shipping to:Australia, Austria, Belgium, Brazil, Bulgaria, Canada, China, Denmark, Finland, France, Germany, Greece, Hungary, Iceland, India, Ireland, Italy, Japan, Latvia, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, United Arab Emirates, United Kingdom, United States
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