Anti-Acetyl-CoA-Carboxylase 1 Antibody

This antibody targets Acetyl-CoA Carboxylase 1 (ACC1), the rate-limiting enzyme in the de novo fatty acid synthesis pathway. Located in the cytosol, ACC1 catalyzes the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA, the primary building block for the synthesis of new long-chain fatty acids. As a critical regulatory node in cellular metabolism, ACC1 activity is tightly controlled by allosteric mechanisms (e.g., activation by citrate) and post-translational modifications, such as inhibitory phosphorylation by AMPK, which senses cellular energy status.

Validated for applications including immunofluorescence, immunohistochemistry, and flow cytometry, this antibody is an essential tool for studying lipogenesis, cellular energy sensing, and metabolic regulation. It is widely used in research on metabolic diseases such as obesity, non-alcoholic fatty liver disease (NAFLD), and diabetes, as well as in cancer biology, where the fatty acid synthesis pathway is frequently upregulated to support rapid cell proliferation.