Anti-14-3-3 zeta Antibody

This antibody targets the 14-3-3 zeta protein (encoded by the YWHAZ gene), an isoform within the ubiquitous 14-3-3 family of regulatory proteins. Like other family members, 14-3-3 zeta acts as a molecular scaffold, binding to phosphorylated client proteins to modulate their function. It is involved in controlling critical signaling pathways, including those regulating the cell cycle (e.g., by sequestering CDC25), apoptosis (e.g., by binding BAD), and MAPK signaling cascades.

This antibody is suitable for applications including immunofluorescence, immunohistochemistry, and flow cytometry, allowing for the study of signal transduction, cell cycle checkpoints, and apoptosis regulation. It helps researchers investigate the specific roles and targets of the 14-3-3 zeta isoform in various cellular contexts.